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Biological Factors > Pigments, Biological > Pterins > Aminopterin > Methotrexate
... > Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Pteridines > Pterins > Aminopterin > Methotrexate

Preferred term

Methotrexate  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Amethopterin

Scope note

  • An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

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URI

http://www.yso.fi/onto/mesh/D008727

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