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Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxidoreductases Acting on CH-NH Group Donors > Methylenetetrahydrofolate Dehydrogenase (NADP)

Preferred term

Methylenetetrahydrofolate Dehydrogenase (NADP)  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Dehydrogenase, Methylenetetrahydrofolate
  • Methylenetetrahydrofolate Dehydrogenase
  • Methylenetetrahydrofolate Dehydrogenase (NADP+)

Note

  • do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)

Scope note

  • An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.

History note

  • 2004(1975);

In other languages

URI

http://www.yso.fi/onto/mesh/D008754

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