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Concept information

Preferred term

Nitric Oxide  

Type

  • Topical Descriptor

Entry terms

  • Endogenous Nitrate Vasodilator
  • Endothelium-Derived Nitric Oxide
  • Mononitrogen Monoxide
  • Monoxide, Mononitrogen
  • Monoxide, Nitrogen
  • Nitrate Vasodilator, Endogenous
  • Nitric Oxide, Endothelium Derived
  • Nitric Oxide, Endothelium-Derived
  • Nitrogen Monoxide
  • Vasodilator, Endogenous Nitrate

Scope note

  • A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

History note

  • 1965

In other languages

URI

http://www.yso.fi/onto/mesh/D009569

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