Concept information
Preferred term
Nitric Oxide
Type
-
Topical Descriptor
Broader concept
Entry terms
- Endogenous Nitrate Vasodilator
- Endothelium-Derived Nitric Oxide
- Mononitrogen Monoxide
- Monoxide, Mononitrogen
- Monoxide, Nitrogen
- Nitrate Vasodilator, Endogenous
- Nitric Oxide, Endothelium Derived
- Nitric Oxide, Endothelium-Derived
- Nitrogen Monoxide
- Vasodilator, Endogenous Nitrate
Scope note
- A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
History note
- 1965
In other languages
-
Finnish
-
Inomax
-
NO
-
typpimonoksidi
-
Swedish
-
Endotelderiverad relaxerande faktor
URI
http://www.yso.fi/onto/mesh/D009569
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