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Investigative Techniques > Genetic Techniques > Nucleic Acid Denaturation
Genetic Phenomena > Nucleic Acid Denaturation
Chemical Phenomena > Biochemical Phenomena > Nucleic Acid Denaturation

Preferred term

Nucleic Acid Denaturation  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Denaturation, DNA
  • Denaturation, RNA
  • DNA Denaturation
  • RNA Denaturation

Note

  • IM general only; coord NIM with DNA or RNA or specific (IM)

Scope note

  • Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.

History note

  • 70(67)

In other languages

URI

http://www.yso.fi/onto/mesh/D009691

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