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Biological Factors > Toxins, Biological > Picrotoxin
Organic Chemicals > Hydrocarbons > Terpenes > Sesquiterpenes > Picrotoxin
Organic Chemicals > Lactones > Picrotoxin
Pharmaceutical Preparations > Plant Extracts > Picrotoxin
Complex Mixtures > Biological Products > Plant Preparations > Plant Extracts > Picrotoxin
Polycyclic Compounds > Macrocyclic Compounds > Cycloparaffins > Cyclohexanes > Picrotoxin
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Alicyclic > Cycloparaffins > Cyclohexanes > Picrotoxin

Preferred term

Picrotoxin  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8
  • Cocculin

Scope note

  • A mixture of PICROTOXININ and PICROTIN that is a noncompetitive antagonist at GABA-A receptors acting as a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.

History note

  • 1966

In other languages

URI

http://www.yso.fi/onto/mesh/D010852

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