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Amino Acids, Peptides, and Proteins > Proteins > Protein Precursors > Proinsulin
... > Chemical Actions and Uses > Pharmacologic Actions > Physiological Effects of Drugs > Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Peptide Hormones > Pancreatic Hormones > Insulins > Proinsulin
... > Amino Acids, Peptides, and Proteins > Peptides > Peptide Hormones > Pancreatic Hormones > Insulins > Proinsulin

Preferred term

Proinsulin  

Type

  • Topical Descriptor

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Narrower concepts

Scope note

  • A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.

History note

  • 72

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URI

http://www.yso.fi/onto/mesh/D011384

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