Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Serum Globulins > Immunoglobulins > Paraproteins > Pyroglobulins
... > Amino Acids, Peptides, and Proteins > Proteins > Globulins > Serum Globulins > Immunoglobulins > Paraproteins > Pyroglobulins
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Immunoglobulins > Paraproteins > Pyroglobulins

Preferred term

Pyroglobulins  

Type

  • Topical Descriptor

Broader concept

Scope note

  • Atypical gamma immunoglobulins characterized by their irreversible heat denaturation at 56-degrees C. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence of pyroglobulins in the serum is the cause of pyroglobulinemia. They are frequently present in multiple myeloma and the pyroglobulin precipitate binds complement, reacts with rheumatoid factor, produces passive cutaneous anaphylaxis, generalized passive anaphylaxis and passive Arthus-type phenomena.

History note

  • 91(76); was see under PARAPROTEINS 1976-90

In other languages

URI

http://www.yso.fi/onto/mesh/D011750

Download this concept:

RDF/XML TURTLE JSON-LD Created 8/1/75, last modified 6/30/05