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Macromolecular Substances > Multiprotein Complexes > Multienzyme Complexes > Pyruvate Dehydrogenase Complex
Enzymes and Coenzymes > Enzymes > Multienzyme Complexes > Pyruvate Dehydrogenase Complex

Preferred term

Pyruvate Dehydrogenase Complex  

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  • Topical Descriptor

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Scope note

  • A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

History note

  • 74(73)

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URI

http://www.yso.fi/onto/mesh/D011768

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