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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Lipoprotein > Receptors, LDL

Preferred term

Receptors, LDL  

Type

  • Topical Descriptor

Broader concept

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Entry terms

  • LDL Receptor
  • LDL Receptors
  • LDL Receptors, Lipoprotein
  • Lipoprotein LDL Receptors
  • Low Density Lipoprotein Receptor
  • Low Density Lipoprotein Receptors
  • Receptor, LDL
  • Receptors, Lipoprotein LDL
  • Receptors, Lipoprotein, LDL
  • Receptors, Low Density Lipoprotein

Scope note

  • Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

History note

  • 85; LIPOPROTEINS, LDL RECEPTORS was see RECEPTORS, LDL 1985-92

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URI

http://www.yso.fi/onto/mesh/D011973

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