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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Steroid 12-alpha-Hydroxylase
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Steroid 12-alpha-Hydroxylase
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Steroid 12-alpha-Hydroxylase
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 8 > Steroid 12-alpha-Hydroxylase
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 8 > Steroid 12-alpha-Hydroxylase
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 8 > Steroid 12-alpha-Hydroxylase

Preferred term

Steroid 12-alpha-Hydroxylase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 12 alpha Hydroxylase
  • 12-alpha-Hydroxylase
  • 12alpha Hydroxylase
  • 12alpha-Hydroxylase
  • 12 alpha-Hydroxylase, Sterol
  • alpha-Hydroxylase, Sterol 12
  • CYP8B1
  • Cytochrome P450 8B1
  • Cytochrome P450 CYP8B1
  • Steroid 12 Hydroxylase
  • Steroid 12-Hydroxylase
  • Steroid-12-Hydroxylase
  • Steroid 12 Monooxygenase
  • Steroid 12-Monooxygenase
  • Steroid-12-Monooxygenase
  • Sterol 12 alpha Hydroxylase
  • Sterol 12 alpha-Hydroxylase
  • Sterol 12-alpha-Hydroxylase

Scope note

  • A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.

History note

  • 2003 (1978)

In other languages

URI

http://www.yso.fi/onto/mesh/D013253

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