Concept information
Preferred term
Teniposide
Type
-
Topical Descriptor
Broader concept
Entry terms
- Demethyl Epipodophyllotoxin Thenylidine Glucoside
Scope note
- A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
History note
- 91(81); was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80
In other languages
-
Finnish
-
Swedish
URI
http://www.yso.fi/onto/mesh/D013713
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