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Concept information

Biological Factors > Toxins, Biological > Bacterial Toxins > Tetanus Toxin
Amino Acids, Peptides, and Proteins > Proteins > Bacterial Proteins > Tetanus Toxin

Preferred term

Tetanus Toxin  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Clostridium tetani Toxin
  • Tetanus Toxins
  • Toxin, Clostridium tetani
  • Toxins, Tetanus

Note

  • /antag permitted but consider also TETANUS ANTITOXIN

Scope note

  • Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.

History note

  • 65

In other languages

URI

http://www.yso.fi/onto/mesh/D013744

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