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Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxidoreductases Acting on CH-NH Group Donors > Tetrahydrofolate Dehydrogenase

Preferred term

Tetrahydrofolate Dehydrogenase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Acid Reductase, Folic
  • Dehydrogenase, Dihydrofolate
  • Dihydrofolate Dehydrogenase
  • Dihydrofolate Reductase
  • Folic Acid Reductase
  • Reductase, Dihydrofolate
  • Reductase, Folic Acid

Scope note

  • An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.

History note

  • 66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88

In other languages

URI

http://www.yso.fi/onto/mesh/D013762

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