Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Piperidines > Piperidones > Thalidomide
Organic Chemicals > Imides > Phthalimides > Thalidomide
... > Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Isoindoles > Phthalimides > Thalidomide
... > Organic Chemicals > Carboxylic Acids > Acids, Carbocyclic > Phthalic Acids > Phthalimides > Thalidomide

Preferred term

Thalidomide  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Sedoval
  • Thalomid

Scope note

  • A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

In other languages

URI

http://www.yso.fi/onto/mesh/D013792

Download this concept:

RDF/XML TURTLE JSON-LD Created 1/1/99, last modified 5/24/17