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Concept information

Metabolism > Pharmacokinetics > Tissue Distribution
Physiological Phenomena > Pharmacological and Toxicological Phenomena > Pharmacokinetics > Tissue Distribution

Preferred term

Tissue Distribution  

Type

  • Topical Descriptor

Broader concept

Note

  • general only: not a substitute for organ /metab or organ /chem; usually NIM; coordinate with substance /pharmacokin or /metab

Scope note

  • Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

History note

  • 78

In other languages

URI

http://www.yso.fi/onto/mesh/D014018

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