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Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Acute-Phase Proteins > Trypsin Inhibitor, Kazal Pancreatic
Amino Acids, Peptides, and Proteins > Proteins > Proteinase Inhibitory Proteins, Secretory > Serine Peptidase Inhibitors, Kazal Type > Trypsin Inhibitor, Kazal Pancreatic
Amino Acids, Peptides, and Proteins > Peptides > Proteinase Inhibitory Proteins, Secretory > Serine Peptidase Inhibitors, Kazal Type > Trypsin Inhibitor, Kazal Pancreatic
... > Chemical Actions and Uses > Pharmacologic Actions > Molecular Mechanisms of Pharmacological Action > Enzyme Inhibitors > Protease Inhibitors > Serine Proteinase Inhibitors > Serine Peptidase Inhibitors, Kazal Type > Trypsin Inhibitor, Kazal Pancreatic

Preferred term

Trypsin Inhibitor, Kazal Pancreatic  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Acidic Pancreatic Trypsin Inhibitor
  • Inhibitor, Tumor-Associated Trypsin
  • Kazal Pancreatic Trypsin Inhibitor
  • Pancreatic Secretory Trypsin Inhibitor
  • Pancreatic Secretory Trypsin Inhibitor, Kazal
  • Pancreatic Trypsin Secretory Inhibitor, Kazal
  • Serine Peptidase Inhibitor, Kazal Type 1
  • Serine Peptidase Inhibitor, Kazal-Type 1
  • Serine Protease Inhibitor Kazal Type 1
  • Serine Protease Inhibitor Kazal-Type 1
  • SPINK1
  • Trypsin Inhibitor Kazal Pancreatic
  • Trypsin Inhibitor, Pancreatic Secretory
  • Trypsin Inhibitor, Tumor Associated
  • Trypsin Inhibitor, Tumor-Associated
  • Tumor Associated Trypsin Inhibitor
  • Tumor-Associated Trypsin Inhibitor

Scope note

  • A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.

History note

  • 91(75); was see under TRYPSIN INHIBITORS 1975-90

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URI

http://www.yso.fi/onto/mesh/D014359

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