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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 27 > 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 27 > 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 27 > 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

Preferred term

25-Hydroxyvitamin D3 1-alpha-Hydroxylase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
  • 1-alpha-Hydroxylase, 25-Hydroxyvitamin D
  • 1-hydroxylase, 25-Hydroxyvitamin D2
  • 25 Hydroxycholecalciferol 1 Hydroxylase
  • 25-Hydroxycholecalciferol 1-Hydroxylase
  • 25-Hydroxycholecalciferol-1-Hydroxylase
  • 25 Hydroxyergocalciferol 1 alpha Hydroxylase
  • 25-Hydroxyergocalciferol 1-alpha-Hydroxylase
  • 25 Hydroxyvitamin D 1 alpha Hydroxylase
  • 25-Hydroxyvitamin D 1-alpha-Hydroxylase
  • 25 Hydroxyvitamin D2 1 hydroxylase
  • 25-Hydroxyvitamin D2 1-hydroxylase
  • 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
  • Calcidiol 1 Monooxygenase
  • Calcidiol 1-Monooxygenase
  • CYP27B1
  • Cytochrome P 450 CYP27B1
  • Cytochrome P-450 CYP27B1

Scope note

  • A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

History note

  • 2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002

In other languages

URI

http://www.yso.fi/onto/mesh/D015090

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