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... > Organic Chemicals > Carboxylic Acids > Acids, Acyclic > Dicarboxylic Acids > Glutarates > Meglutol

Preferred term

Meglutol  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 3 Hydroxy 3 methylglutaric Acid
  • 3-Hydroxy-3-methylglutaric Acid
  • 3 Hydroxy 3 methylpentanedioic Acid
  • 3-Hydroxy-3-methylpentanedioic Acid
  • Acid, 3-Hydroxy-3-methylglutaric
  • Acid, 3-Hydroxy-3-methylpentanedioic
  • beta Hydroxy beta Methylglutarate
  • beta-Hydroxy-beta-Methylglutarate

Scope note

  • An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.

History note

  • 96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)

In other languages

URI

http://www.yso.fi/onto/mesh/D015093

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