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... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrimidines > Pyrimidine Nucleosides > Thymidine > Zidovudine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Pyrimidine Nucleosides > Thymidine > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Pyrimidine Nucleosides > Thymidine > Zidovudine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Thymidine > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Thymidine > Zidovudine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zidovudine

Preferred term

Zidovudine  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 3' Azido 2',3' Dideoxythymidine
  • 3'-Azido-2',3'-Dideoxythymidine
  • 3' Azido 3' deoxythymidine
  • 3'-Azido-3'-deoxythymidine
  • Antiviral AZT
  • Azidothymidine
  • AZT (Antiviral)
  • AZT Antiviral
  • AZT, Antiviral

Scope note

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.

History note

  • 89

In other languages

  • tsidovudiini

    Finnish

  • atsidotymidiini
  • Azt
  • Retrovir
  • Zidovudin

    Swedish

  • Azidotymidin
  • AZT-antiviral
  • Retrovir

URI

http://www.yso.fi/onto/mesh/D015215

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