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Concept information

Metabolism > Energy Metabolism > Substrate Cycling
Chemical Phenomena > Biochemical Phenomena > Substrate Cycling

Preferred term

Substrate Cycling  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Cycle, Futile
  • Cycles, Futile
  • Futile Cycle
  • Futile Cycles

Note

  • restricted to enzyme activity; almost never IM; coord NIM with specific enzyme (IM)

Scope note

  • A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.

History note

  • 89

In other languages

URI

http://www.yso.fi/onto/mesh/D015219

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