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Biological Factors > Blood Coagulation Factors > Fibrinogen > Fibrinogens, Abnormal
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Blood Coagulation Factors > Fibrinogen > Fibrinogens, Abnormal
Amino Acids, Peptides, and Proteins > Proteins > Protein Precursors > Fibrinogen > Fibrinogens, Abnormal
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Acute-Phase Proteins > Fibrinogen > Fibrinogens, Abnormal

Preferred term

Fibrinogens, Abnormal  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Abnormal Fibrinogens

Scope note

  • Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.

History note

  • 89

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URI

http://www.yso.fi/onto/mesh/D015241

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