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Biological Factors > Antigens > Antigens, Neoplasm > Neprilysin
Biological Factors > Biomarkers > Biomarkers, Tumor > Neprilysin
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Metalloendopeptidases > Neprilysin
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Metalloproteases > Metalloendopeptidases > Neprilysin

Preferred term

Neprilysin  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Antigen, CD10
  • Antigens, CD10
  • Antigens, Leukemia, Common Acute Lymphoblastic
  • Atriopeptidase
  • CALLA Antigen
  • Carboxypeptidase, Enkephalin Dipeptidyl
  • CD10 Antigen
  • CD10 Antigens
  • Common Acute Lymphoblastic Leukemia Antigens
  • Dipeptidyl Carboxypeptidase, Enkephalin
  • Endopeptidase 24.11
  • Endopeptidase-24.11
  • Endopeptidase 24.11, Neutral
  • Endopeptidase, Neutral
  • Enkephalinase
  • Enkephalinase 24.11
  • Enkephalinase-24.11
  • Enkephalin Dipeptidyl Carboxypeptidase
  • Enzyme, YGG-Forming
  • Kidney Brush Border Neutral Proteinase
  • Kidney-Brush-Border Neutral Proteinase
  • Membrane Metallo Endopeptidase
  • Membrane Metallo-Endopeptidase
  • Metallo-Endopeptidase, Membrane
  • Metalloendopeptidase, Thermolysin-Like
  • Neutral Endopeptidase
  • Neutral Endopeptidase 24.11
  • Neutral Proteinase, Kidney-Brush-Border
  • Thermolysin Like Metalloendopeptidase
  • Thermolysin-Like Metalloendopeptidase
  • YGG Forming Enzyme
  • YGG-Forming Enzyme

Scope note

  • Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

History note

  • 1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS (NM) 1983-92

In other languages

URI

http://www.yso.fi/onto/mesh/D015260

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