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Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > Nucleic Acid Probes > DNA Probes
... > Chemical Actions and Uses > Specialty Uses of Chemicals > Laboratory Chemicals > Molecular Probes > Nucleic Acid Probes > DNA Probes
... > Chemical Actions and Uses > Pharmacologic Actions > Diagnostic Uses of Chemicals > Molecular Probes > Nucleic Acid Probes > DNA Probes

Preferred term

DNA Probes  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Related concepts

Entry terms

  • DNA Hybridization Probe
  • DNA Hybridization Probes
  • DNA Probe
  • Hybridization Probe, DNA
  • Hybridization Probes, DNA
  • Probe, DNA
  • Probe, DNA Hybridization
  • Probes, DNA Hybridization

Note

  • general or unspecified; prefer specifics

Scope note

  • Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.

History note

  • 89

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URI

http://www.yso.fi/onto/mesh/D015342

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