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Lipids > Fatty Acids > Fatty Acids, Unsaturated > Fatty Acids, Monounsaturated > Cilastatin
Polycyclic Compounds > Macrocyclic Compounds > Cycloparaffins > Cyclopropanes > Cilastatin
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Alicyclic > Cycloparaffins > Cyclopropanes > Cilastatin

Preferred term

Cilastatin  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • Cilastatin Sodium
  • MK 0791
  • Sodium, Cilastatin

Scope note

  • A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

History note

  • 89

In other languages

URI

http://www.yso.fi/onto/mesh/D015377

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