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... > Nervous System Diseases > Neuromuscular Diseases > Peripheral Nervous System Diseases > Polyneuropathies > Hereditary Sensory and Motor Neuropathy > Spastic Paraplegia, Hereditary
Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Genetic Diseases, Inborn > Heredodegenerative Disorders, Nervous System > Hereditary Sensory and Motor Neuropathy > Spastic Paraplegia, Hereditary
Nervous System Diseases > Neurodegenerative Diseases > Heredodegenerative Disorders, Nervous System > Hereditary Sensory and Motor Neuropathy > Spastic Paraplegia, Hereditary
Nervous System Diseases > Nervous System Malformations > Hereditary Sensory and Motor Neuropathy > Spastic Paraplegia, Hereditary
Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Congenital Abnormalities > Nervous System Malformations > Hereditary Sensory and Motor Neuropathy > Spastic Paraplegia, Hereditary

Preferred term

Spastic Paraplegia, Hereditary  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Hereditary Spastic Paraplegia
  • Hereditary Spastic Paraplegias
  • Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia
  • Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia
  • Paraplegia, Hereditary Spastic
  • Paraplegias, Hereditary Spastic
  • Paraplegia, Spastic, Hereditary
  • Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy
  • Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy
  • Spastic Paraplegias, Hereditary

Note

  • coordinate with GENES, DOMINANT or GENES, RECESSIVE if discussed

Scope note

  • A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)

History note

  • 1991(1989)

In other languages

  • perinnöllinen spastinen paraplegia

    Finnish

  • hereditaarinen spastinen paraplegia
  • hereditär spastisk parapares
  • hereditäärinen spastinen paraplegia
  • paraplegia spastica hereditaria
  • periytyvä spastinen paraplegia
  • Hereditär spastisk paraplegi

    Swedish

  • Hereditär spastisk parapares
  • Spastisk paraplegi typ 2
  • Ärftlig spastisk paraplegi

URI

http://www.yso.fi/onto/mesh/D015419

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