Concept information
Preferred term
Giant Cells
Type
-
Topical Descriptor
Broader concept
Narrower concepts
Entry terms
- Cell, Multinucleated Giant
- Cells, Multinucleated Giant
- Giant Cell, Multinucleated
- Giant Cells, Multinucleated
- Multinucleated Giant Cell
- Multinucleated Giant Cells
- Polykaryocyte
- Polykaryocytes
- Syncytia
- Syncytium
Scope note
- Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
History note
- 90
In other languages
-
Finnish
-
jättisolu
-
Swedish
URI
http://www.yso.fi/onto/mesh/D015726
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