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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement C1 > Complement C1q

Preferred term

Complement C1q  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • C1q Complement
  • Complement 1q
  • Complement, C1q
  • Complement Component 1q
  • Component 1q, Complement

Scope note

  • A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.

History note

  • 2006 (1990)

In other languages

URI

http://www.yso.fi/onto/mesh/D015922

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