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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement C1 > Complement C1r
Enzymes and Coenzymes > Enzymes > Hydrolases > Complement Activating Enzymes > Complement C1r
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Activating Enzymes > Complement C1r

Preferred term

Complement C1r  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • C1r Complement
  • Complement 1r
  • Complement, C1r
  • Complement Component 1r
  • Component 1r, Complement

Scope note

  • A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.

History note

  • 2006 (1990)

In other languages

URI

http://www.yso.fi/onto/mesh/D015923

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