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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement C5 > Complement C5a
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Anaphylatoxins > Complement C5a

Preferred term

Complement C5a  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • C5a Complement
  • Complement 5a
  • Complement, C5a
  • Complement Component 5a
  • Component 5a, Complement

Scope note

  • The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.

History note

  • 2006 (1990)

In other languages

URI

http://www.yso.fi/onto/mesh/D015936

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