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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Blood Coagulation Factors > Factor VIII > Factor VIIIa
Biological Factors > Blood Coagulation Factors > Factor VIII > Factor VIIIa
Amino Acids, Peptides, and Proteins > Proteins > Protein Precursors > Factor VIII > Factor VIIIa

Preferred term

Factor VIIIa  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Activated Factor VIII
  • Blood Coagulation Factor VIII, Activated
  • Coagulation Factor VIIIa
  • Factor 8A
  • Factor Eight A
  • Factor VIIIa, Coagulation
  • Factor VIII, Activated
  • Factor VIII, Thrombin Activated
  • Factor VIII, Thrombin-Activated
  • Thrombin-Activated Factor VIII

Scope note

  • Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.

History note

  • 90

In other languages

URI

http://www.yso.fi/onto/mesh/D015944

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