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Biological Factors > Blood Coagulation Factors > Factor XII > Factor XIIa
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Blood Coagulation Factors > Factor XII > Factor XIIa
... > Amino Acids, Peptides, and Proteins > Proteins > Protein Precursors > Enzyme Precursors > Factor XII > Factor XIIa
Enzymes and Coenzymes > Enzyme Precursors > Factor XII > Factor XIIa
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Serine Endopeptidases > Factor XIIa
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Serine Proteases > Serine Endopeptidases > Factor XIIa

Preferred term

Factor XIIa  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Activated Factor XII
  • Activator, Prekallikrein
  • Blood Coagulation Factor XII, Activated
  • Coagulation Factor XIIa
  • Factor 12A
  • Factor Twelve A
  • Factor XIIa, Coagulation
  • Factor XII, Activated
  • Prekallikrein Activator

Note

  • /defic = FACTOR XII DEFICIENCY

Scope note

  • Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.

History note

  • 90

In other languages

URI

http://www.yso.fi/onto/mesh/D015956

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