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Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Deoxycytidine > Zalcitabine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Deoxycytidine > Zalcitabine
... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Ribonucleosides > Cytidine > Deoxycytidine > Zalcitabine
... > Carbohydrates > Glycosides > Nucleosides > Ribonucleosides > Cytidine > Deoxycytidine > Zalcitabine
... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrimidines > Pyrimidine Nucleosides > Cytidine > Deoxycytidine > Zalcitabine
... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Pyrimidine Nucleosides > Cytidine > Deoxycytidine > Zalcitabine
... > Carbohydrates > Glycosides > Nucleosides > Pyrimidine Nucleosides > Cytidine > Deoxycytidine > Zalcitabine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zalcitabine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zalcitabine

Preferred term

Zalcitabine  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Entry terms

  • 2',3' Dideoxycytidine
  • 2',3'-Dideoxycytidine
  • ddC (Antiviral)
  • Dideoxycytidine

Scope note

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.

History note

  • 94; was DIDEOXYCYTIDINE 1990-93

In other languages

URI

http://www.yso.fi/onto/mesh/D016047

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