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... > Carbohydrates > Glycosides > Nucleosides > Ribonucleosides > Inosine > Didanosine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Ribonucleosides > Inosine > Didanosine
... > Carbohydrates > Glycosides > Nucleosides > Purine Nucleosides > Inosine > Didanosine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Purine Nucleosides > Inosine > Didanosine
... > Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Purines > Purine Nucleosides > Inosine > Didanosine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Didanosine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Didanosine

Preferred term

Didanosine  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 2',3' Dideoxyinosine
  • 2',3'-Dideoxyinosine
  • ddI (Antiviral)
  • Dideoxyinosine

Scope note

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.

History note

  • 92; was DIDEOXYINOSINE 1990-91

In other languages

URI

http://www.yso.fi/onto/mesh/D016049

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