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... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > Ion Channels > Ligand-Gated Ion Channels > Receptors, Ionotropic Glutamate > Receptors, N-Methyl-D-Aspartate
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > Ion Channels > Ligand-Gated Ion Channels > Receptors, Ionotropic Glutamate > Receptors, N-Methyl-D-Aspartate
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > Ion Channels > Ligand-Gated Ion Channels > Receptors, Ionotropic Glutamate > Receptors, N-Methyl-D-Aspartate
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > Ion Channels > Ligand-Gated Ion Channels > Receptors, Ionotropic Glutamate > Receptors, N-Methyl-D-Aspartate
... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > Ion Channels > Ligand-Gated Ion Channels > Receptors, Ionotropic Glutamate > Receptors, N-Methyl-D-Aspartate
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Neurotransmitter > Receptors, Amino Acid > Receptors, Glutamate > Receptors, Ionotropic Glutamate > Receptors, N-Methyl-D-Aspartate

Preferred term

Receptors, N-Methyl-D-Aspartate  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • NMDA Receptor
  • NMDA Receptor Ionophore Complex
  • NMDA Receptor-Ionophore Complex
  • NMDA Receptors
  • N Methylaspartate Receptors
  • N-Methylaspartate Receptors
  • N Methyl D Aspartate Receptor
  • N-Methyl-D-Aspartate Receptor
  • N Methyl D Aspartate Receptors
  • N-Methyl-D-Aspartate Receptors
  • Receptor, NMDA
  • Receptor, N-Methyl-D-Aspartate
  • Receptors, NMDA
  • Receptors, N Methylaspartate
  • Receptors, N-Methylaspartate

Scope note

  • A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

History note

  • 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92

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URI

http://www.yso.fi/onto/mesh/D016194

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