Concept information
Amino Acids, Peptides, and Proteins
Proteins
Intercellular Signaling Peptides and Proteins
Cytokines
Amino Acids, Peptides, and Proteins
Peptides
Intercellular Signaling Peptides and Proteins
Cytokines
Preferred term
Transforming Growth Factor beta
Type
-
Topical Descriptor
Broader concept
Narrower concepts
Entry terms
- Bone Derived Transforming Growth Factor
- Bone-Derived Transforming Growth Factor
- Factor, Milk Growth
- Growth Factor, Milk
- Milk Growth Factor
- Platelet Transforming Growth Factor
- TGF-beta
- TGFbeta
Scope note
- A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
History note
- 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90
In other languages
-
Finnish
-
kasvainkasvutekijä beeta
-
TGF-beeta
-
Swedish
URI
http://www.yso.fi/onto/mesh/D016212
{{label}}
{{#each values }} {{! loop through ConceptPropertyValue objects }}
{{#if prefLabel }}
{{/if}}
{{/each}}
{{#if notation }}{{ notation }} {{/if}}{{ prefLabel }}
{{#ifDifferentLabelLang lang }} ({{ lang }}){{/ifDifferentLabelLang}}
{{#if vocabName }}
{{ vocabName }}
{{/if}}