Concept information
Preferred term
Mutagenesis, Insertional
Type
-
Topical Descriptor
Broader concept
Entry terms
- Insertional Mutagenesis
Scope note
- Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
History note
- 91
In other languages
-
Finnish
-
insertiomutageneesi
-
Swedish
URI
http://www.yso.fi/onto/mesh/D016254
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