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Concept information

Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Quinazolines > Trimetrexate

Preferred term

Trimetrexate  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • CI 898
  • CI-898
  • CI898
  • Hydrate, Trimetrexate
  • JB 11
  • JB-11
  • JB11
  • Monohydrate, Monoacetate Trimetrexate
  • NSC 249008
  • NSC-249008
  • NSC249008
  • NSC 328564
  • NSC-328564
  • NSC328564
  • Trimetrexate Hydrate
  • Trimetrexate Monohydrate, Monoacetate

Scope note

  • A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

History note

  • 92; was TRIMETREXATE (NM) 1979-91

In other languages

URI

http://www.yso.fi/onto/mesh/D016597

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