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... > Investigative Techniques > Clinical Laboratory Techniques > Histological Techniques > Histocytological Preparation Techniques > Staining and Labeling > Negative Staining
... > Diagnosis > Diagnostic Techniques and Procedures > Clinical Laboratory Techniques > Histological Techniques > Histocytological Preparation Techniques > Staining and Labeling > Negative Staining
... > Investigative Techniques > Clinical Laboratory Techniques > Cytological Techniques > Histocytological Preparation Techniques > Staining and Labeling > Negative Staining
... > Diagnosis > Diagnostic Techniques and Procedures > Clinical Laboratory Techniques > Cytological Techniques > Histocytological Preparation Techniques > Staining and Labeling > Negative Staining

Preferred term

Negative Staining  

Type

  • Topical Descriptor

Broader concept

Scope note

  • The technique of washing tissue specimens with a concentrated solution of a heavy metal salt and letting it dry. The specimen will be covered with a very thin layer of the metal salt, being excluded in areas where an adsorbed macromolecule is present. The macromolecules allow electrons from the beam of an electron microscope to pass much more readily than the heavy metal; thus, a reversed or negative image of the molecule is created.

History note

  • 92

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URI

http://www.yso.fi/onto/mesh/D016624

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