Concept information
Preferred term
Neurofilament Proteins
Type
-
Topical Descriptor
Broader concept
Entry terms
- Neurofilament Protein
- Protein, Neurofilament
Note
- /biosyn /physiol permitted
Scope note
- Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
History note
- 92; was NEUROFILAMENT PROTEINS (NM) 1977-91
In other languages
-
Finnish
-
neurofilamenttiproteiini
-
Swedish
URI
http://www.yso.fi/onto/mesh/D016900
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