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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Serine Endopeptidases > Complement Factor I
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Serine Proteases > Serine Endopeptidases > Complement Factor I
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Inactivator Proteins > Complement C3b Inactivator Proteins > Complement Factor I

Preferred term

Complement Factor I  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • C3b C4b Inactivator
  • C3b-C4b Inactivator
  • C3b Inactivator
  • C4b C3b INA
  • C4b-C3b-INA
  • C4bC3bINA
  • C4b-C3b Inactivator, Complement
  • Complement 3b Complement 4b Inactivator
  • Complement 3b-Complement 4b Inactivator
  • Complement C4b C3b Inactivator
  • Complement C4b-C3b Inactivator
  • Inactivator, C3b
  • Inactivator, C3b-C4b
  • Inactivator, Complement C4b-C3b

Note

  • do not confuse with FACTOR I see FIBRINOGEN

Scope note

  • A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.

History note

  • 93; was FACTOR I, C 3B INACTIVATOR (NM) 1983-92

In other languages

URI

http://www.yso.fi/onto/mesh/D017244

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RDF/XML TURTLE JSON-LD Created 5/7/92, last modified 7/6/09