Concept information
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Proteins
Intracellular Signaling Peptides and Proteins
Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases
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Peptides
Intracellular Signaling Peptides and Proteins
Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases
Preferred term
Receptor, IGF Type 1
Type
-
Topical Descriptor
Broader concept
Entry terms
- IGF 1 Receptor
- IGF-1 Receptor
- IGF-1 Receptors
- IGF I Receptor
- IGF-I Receptor
- IGF Type 1 Receptor
- Insulin Like Growth Factor I Receptor
- Insulin-Like-Growth Factor I Receptor
- Receptor, IGF-1
- Receptor, IGF I
- Receptor, IGF-I
- Receptor, Insulin-Like Growth Factor I
- Receptor, Insulin-Like Growth Factor Type 1
- Receptors, IGF 1
- Receptors, IGF-1
- Receptors, Insulin-Like-Growth Factor I
Scope note
- A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
History note
- 2000(1993);
In other languages
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Finnish
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IGF-1-reseptori
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Swedish
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IGF typ 1 alfa subenhet receptor
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IGF typ 1 beta subenhet receptor
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IGF-I-receptor
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Insulinliknande tillväxtfaktor I-receptor
URI
http://www.yso.fi/onto/mesh/D017526
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