Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

... > Lipids > Fatty Acids > Fatty Acids, Unsaturated > Fatty Acids, Essential > Arachidonic Acids > Leukotrienes > Leukotriene A4
... > Biological Factors > Inflammation Mediators > Autacoids > Eicosanoids > Arachidonic Acids > Leukotrienes > Leukotriene A4
... > Lipids > Fatty Acids > Fatty Acids, Unsaturated > Eicosanoids > Arachidonic Acids > Leukotrienes > Leukotriene A4

Preferred term

Leukotriene A4  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Leukotriene A 4
  • Leukotriene A-4
  • LTA4

Note

  • /biosyn /physiol permitted

Scope note

  • (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)

History note

  • 94; was LEUKOTRIENE A (NM) 1980-93

In other languages

URI

http://www.yso.fi/onto/mesh/D017572

Download this concept:

RDF/XML TURTLE JSON-LD Created 6/4/93, last modified 6/8/15