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Immune System Phenomena > Immunogenetic Phenomena > Gene Rearrangement, B-Lymphocyte > Gene Rearrangement, B-Lymphocyte, Heavy Chain > Immunoglobulin Class Switching
Genetic Phenomena > Gene Rearrangement > Gene Rearrangement, B-Lymphocyte > Gene Rearrangement, B-Lymphocyte, Heavy Chain > Immunoglobulin Class Switching

Preferred term

Immunoglobulin Class Switching  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Class Switching
  • Class Switching, Ig
  • Class Switchings
  • Class Switchings, Ig
  • Ig Class Switching
  • Ig Class Switchings
  • Isotype Switching
  • Isotype Switchings
  • Switching, Class
  • Switching, Ig Class
  • Switching, Isotype
  • Switchings, Class
  • Switchings, Ig Class
  • Switchings, Isotype

Scope note

  • Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.

History note

  • 94

In other languages

URI

http://www.yso.fi/onto/mesh/D017578

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RDF/XML TURTLE JSON-LD Created 6/17/93, last modified 7/5/19