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Biological Factors > Antigens > Superantigens

Preferred term

Superantigens  

Type

  • Topical Descriptor

Broader concept

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Entry terms

  • Superantigen

Note

  • coordinate IM with specific microbe /immunol (IM); for interaction of superantigens with endotoxins, coordinate with ENDOTOXINS or specifics

Scope note

  • Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.

History note

  • 94

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URI

http://www.yso.fi/onto/mesh/D018089

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