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... > Eukaryota > Animals > Animal Population Groups > Animals, Laboratory > Animals, Inbred Strains > Mice, Inbred Strains > Mice, Inbred CFTR
... > Eukaryota > Animals > Chordata > Vertebrates > Mammals > Eutheria > Rodentia > Muridae > Murinae > Mice > Mice, Inbred Strains > Mice, Inbred CFTR

Preferred term

Mice, Inbred CFTR  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • CFTR Mice
  • CFTR Mouse
  • CFTR Mouse, Inbred
  • Inbred CFTR Mouse
  • Mice, CFTR
  • Mouse, CFTR
  • Mouse, Inbred CFTR

Note

  • NIM with no qualifiers when experimental animal

Scope note

  • A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.

History note

  • 94

In other languages

URI

http://www.yso.fi/onto/mesh/D018181

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