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... > Eukaryota > Animals > Chordata > Vertebrates > Mammals > Eutheria > Rodentia > Muridae > Murinae > Mice > Mice, Mutant Strains > Mice, Knockout
... > Eukaryota > Animals > Animal Population Groups > Animals, Genetically Modified > Mice, Transgenic > Mice, Knockout
Organism Forms > Organisms, Genetically Modified > Animals, Genetically Modified > Mice, Transgenic > Mice, Knockout
... > Eukaryota > Animals > Chordata > Vertebrates > Mammals > Eutheria > Rodentia > Muridae > Murinae > Mice > Mice, Transgenic > Mice, Knockout

Preferred term

Mice, Knockout  

Type

  • Topical Descriptor

Broader concept

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Entry terms

  • Knock-out Mice
  • Knockout Mice
  • Knockout Mouse
  • Mice, Knock out
  • Mice, Knock-out
  • Mouse, Knockout

Note

  • NIM no qualif when exper animal; do not forget also to check MICE

Scope note

  • Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

History note

  • 94

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URI

http://www.yso.fi/onto/mesh/D018345

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