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... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > ATP-Binding Cassette Transporters > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > Ion Pumps > Anion Transport Proteins > Organic Anion Transporters > Organic Anion Transporters, ATP-Dependent > ATP Binding Cassette Transporter, Subfamily B
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > Ion Pumps > Anion Transport Proteins > Organic Anion Transporters > Organic Anion Transporters, ATP-Dependent > ATP Binding Cassette Transporter, Subfamily B

Preferred term

ATP Binding Cassette Transporter, Subfamily B  

Type

  • Topical Descriptor

Broader concept

Narrower concepts

Related concepts

Entry terms

  • ATP Binding Cassette, Sub Family B Proteins
  • ATP-Binding Cassette, Sub-Family B Proteins
  • ATP Binding Cassette Transporter, Sub Family B
  • ATP Binding Cassette Transporter, Sub-Family B
  • Multidrug Resistance Proteins
  • P Glycoproteins
  • P-Glycoproteins

Note

  • note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available

Scope note

  • A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

History note

  • 2019 (1999); use P-GLYCOPROTEIN 1995-1998

In other languages

URI

http://www.yso.fi/onto/mesh/D018435

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