Concept information
Preferred term
Genes, erbB-2
Type
-
Topical Descriptor
Broader concept
Entry terms
- c-erbB-2 Gene
- c erbB 2 Genes
- c-erbB-2 Genes
- c-erbB-2 Proto-Oncogene
- c erbB 2 Proto Oncogenes
- c-erbB-2 Proto-Oncogenes
- erbB-2 Gene
- erbb2 Gene
- erbB 2 Genes
- erbB-2 Genes
- erbb2 Genes
- Gene, erbb2
- Gene, HER2
- Genes, erbb2
- Genes, HER-2
- Genes, HER2
- Genes, neu
- HER-2 Gene
- HER2 Gene
- HER-2 Genes
- HER2 Genes
- neu Gene
- neu Genes
Note
- in titles & translations spell as erbB-2; GENES, ERBB-1 is also available
Scope note
- The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
History note
- 1995
In other languages
-
Finnish
-
erbB-2-geeni
-
Swedish
-
c-erbB-2 gener
-
c-erbB-2 proto-onkogener
-
erbb2 gener
-
HER-2 gener
-
neu gener
URI
http://www.yso.fi/onto/mesh/D018734
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