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... > Genetic Phenomena > Genetic Structures > Genome > Genome Components > Genes > Genes, Neoplasm > Oncogenes > Proto-Oncogenes > Genes, erbB > Genes, erbB-1

Preferred term

Genes, erbB-1  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • erbB-1 Gene
  • erbB1 Gene
  • erbB 1 Genes
  • erbB-1 Genes
  • erbB1 Genes
  • Gene, erbB1
  • Genes, erbB1

Note

  • spell in titles & translations as erbB-1; GENES, ERBB-2 is also available

Scope note

  • The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.

History note

  • 1995

In other languages

  • erbB-1-geenit

    Finnish

  • erbB-1-geeni
  • erbB-1-gener

    Swedish

  • c-erbB-1 gener
  • c-erbB-1 proto-onkogener
  • EGFR gener
  • v-erbB gener
  • v-erbB onkogener

URI

http://www.yso.fi/onto/mesh/D018773

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