Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

... > Amino Acids, Peptides, and Proteins > Proteins > Viral Proteins > Oncogene Proteins, Viral > Retroviridae Proteins, Oncogenic > Oncogene Proteins v-erbA
... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Oncogene Proteins, Viral > Retroviridae Proteins, Oncogenic > Oncogene Proteins v-erbA
... > Amino Acids, Peptides, and Proteins > Proteins > Viral Proteins > Retroviridae Proteins > Retroviridae Proteins, Oncogenic > Oncogene Proteins v-erbA

Preferred term

Oncogene Proteins v-erbA  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • erbA Oncogene Proteins
  • Oncogene Products v erbA
  • Oncogene Products v-erbA
  • v erbA Proteins
  • v-erbA Proteins

Scope note

  • Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.

History note

  • 95; was ONCOGENE PROTEIN ERBA (NM) 1987-94

In other languages

URI

http://www.yso.fi/onto/mesh/D018774

Download this concept:

RDF/XML TURTLE JSON-LD Created 5/23/94, last modified 7/1/18